乐于官网科学家构建人体免疫发育细胞图谱

　　巨ju噬shi细xi胞bao是shi免mian疫yi系xi统tong中zhong不bu可ke或huo缺que的de组zu成cheng部bu分fen，广guang泛fan分fenbu在zai不bu同tongzuezhi中zhong，并且bing在zai发送fa育yu、guan形状xing、稳wen态tai维wei持chi和heji病bing发fa生sheng发fangzhong发fangzhang发fang关guan键jian作为zuong。巨ju噬shi细胞bao异yi质zhi性xing显示zhuo，主zhu要yao表biao现xian在zai形xing状taing中、定ding位wei、基ji因yin表biaoda谱pu、ji功gong能neng等deng方fang面mian，这zhexie表biao型xing由you巨ju噬shixi胞baode发fa育yu起qi源yuan和he驻zhu留liude微wei环huanjing决定jueding。具ju具有you组zhi特te异ying特te征zhengde巨ju噬shi细胞bao包bao包bao，zhong枢shushen通过jing系xi统tongde小xiao胶jiao质zhi细胞baobao（Microglia）、肝脏zangde枯ku不pixi胞baoo（Kupffer cells）与he表biao皮pide朗lang格子汉han斯si细xi胞baoo（Langerhans cells）等deng。另一个ling有you一yixie分fenbu于yuduo个ge器qi官guande巨ju噬shi细xi胞bao，如ru血xue管guan周zhou围wei巨ju噬shi细胞baoo（Perivascular macrophages）。基ji在yu啮nie齿chilelei动dong物wu的de研yan研究jiu为cheng果guo，学习xuezhu界jiedui巨ju噬shi细胞baoya型xingdededuo样yangxing、发送fa育yu起qi源yuan以yi和ji组zu织zhi特te异yixingdexing为cheng，有you，liao一yiding认ren识shi。然ran和er，这zhexie发fa现xian是shi是否pi适合shi用yong于yu人ren类lei还是reng然ran不知道zhi，特te别bie是shi人ren类lei胚pei胎tai发送fa育yu在guo程cheng中zhong巨ju噬shi细胞baodeduo样yangxing、发送fa育yuyuyuan、功gong可以neng和ji成cheng熟悉shu的de动dong态tai通过guo程cheng等deng问wen题ti缺乏que，而er全quan面mianderyan研究jiu。 9月yue12日ri，中zhong国家guo科学xue学院yuan深shenzhen先xian进入jin技术zhan研究yuan研究yuanyuan优秀jie课程ke题ti组zu联lian、深shenzhen大da学习xuen、上shang海hai交jiao通tong大da学习xue和he复fudan大da学习xue等deng，zai《细xibao》（Cell）上shang，发送fa表biaoliao题ti为weiann immune cell atlas reveals the dynamics of human macrophage specification during prenatal developmentde研yanjiu文wen章zhang。gai团tuan队dui结jieheshan细胞bao转zhuan录音组zu测c、先xian进入jinde生sheng物wu信xin息xi学xue手shou段duan、多do重zhong免疫yining光guang染色、体ti外wai功gong可以neng实shi验yan等deng技jizhu，gou建jianliao横heng跨kua18ge发fa育yu阶jie段duan、19种zhong组zu织zhiderenlei胚pei胎tai免mian疫yi系xi统tong发fa育yu高gao分fen辨bian率shuai图tupu。gai研究yan研究jiu重zhong点dian关guan注zhu最zui具ju组zhi特te异yingde巨ju噬shixibao，鉴jian定dingliangliao15种zhong巨ju噬shi细胞baoya型xing。其qi中zhong，包bao包括kuo两liangzhong新xinde巨ju噬shi细胞bao亚yaxing，即ji存cun在zaiyu表biao皮pi、睾gao丸wan、心脏zang等deng外wai周zhou组zu织zhidelei小xiao胶jiao质zhi细胞bao（Microglia-like cells）与he具ju有you血xue管guan生sheng成cheng促进jin功gong并bing广guang泛fan分fen布bu于yuduo个ge组zuongzhi中zhong的de促进cu血xue管guan生sheng成cheng（Proangiogenic macrophages, PraM）。gai研究yan研究jiu通tong通过guo构gou建jian人ren类lei生产chan前qian免mian疫yi细胞bao发送fa育yudeshi空kong动dong状态taitupu，揭qi显示shiliao多duo种zhong巨ju噬shibaoya型xing在zai发fa育yu通过guo程chengzhong的de分fenhua起qi源yuang、jian定ding间ding、功gong可以neng特te征zheng和ji转zhuan录lu调zhou控制kong机ji制zhi。 gai研究yan研究jiu对dui来lai自zhhou怀孕yun后hou4-26 PCW（Postconceptional Week，PCW）囊ng包括kuo19种zhong人ren类leipei胎tai组zu织zhi样yang本bende免疫yixi细胞bao进入jin行xingliao单shan细胞bao转zhuan录lu组zu测ce序xu，获得huodei，liao近jin30万wan个ge高gao质zhi量liangde免mian疫yi细胞bao(图tu1)，bing鉴jian定dingliao11种zhong主zhu要yaode免mian疫yi细胞baoleing，bao包括kuo巨型ju噬shi细胞baoobao（Macrophages）、祖zu细xibaoo（Progenitor cells）、B 淋上lin巴ba细xibaoooba、T 淋上lin巴ba细xibaoooba、先xian天tian淋上lin巴ba细xibaoooba（Innate-like lymphocytes）、自ziran杀shang（Natural killer cells）、shu突tu状zhuang细x（Dendritic cells）、单shan核hu细胞（Monocytes）、巨型ju核hu细xibao（Megakaryocytes）、粒状细胞xibaooo（Granulocytes）与he红hong细xibaoo（Erythrocytes）。在zai这个ci基ji基chuzhi上shang，研yan研究jiu对dui每个mei一yizhong主zhu要yaode免mian疫yi细胞baolei型xing进入jin行xing，liao更加细xi致zhiden类lei，最zui终zhong注入zhu释shidei到dao56种zhong免疫yi细胞bao亚ya型xing。 科ke研yan人ren员yuan重zhong点dian对dui巨ju噬shixibao开kai展zhan研yan研究jiu，bing将jiang其qi进入jin一yi步bu细xi分fen为wei15个geaya群qun。通tong通过guo时，shi空kong分fen分析xi，研yan研究jiu发fa现xian在zai人ren类lei胚胎tai发fa育yu时shi期qi，巨ju噬shi细xi胞bao便pian已经yi具ju有you显示xian，zhuodezhi特te异ying。在zai4 PCW左zuo右you(器qi官guan初chu形xing成cheng阶jie段duan)，巨ju噬shi细胞bao前qian体ti已yi出chu现在zai胚pei胎tai中zhong，bing一yi直zhi持chi续xu到dao大dai8 PCW，直zhi到dao被pi成cheng熟悉shu的de组zu织zhi驻zhi留下liu巨ju噬shi细胞baosuo代替tidai。zhong在zai这zhexie巨ju噬shi细胞bao中，一yi部bu分fen亚ya型xing具ju有you显xian与zhuode组zu织zhi特te异ying特te征zheng，例如ru中zhong枢shu神shen通过jing系xi统tong中zhong的de小xiao胶jiao质zhi细胞bao、zhong在肝脏zang中的de枯ku不pi细胞baong、表biao皮pi中zhong的de朗lang格子汉han斯si细胞bao等deng。而er另ling一yi部bu分fen亚ya型xing共gong在yuduo个ge组zu织zhi中zhong，如Ru促cu血xue管guan生sheng成cheng巨ju噬shi细胞baoyi和ji其qi前qian体ti细胞baoo（pre-Proangiogenic macrophages, pre-PraM）。研yan研究jiu还huan发送fa现xian，在肾shen上shangxian中zhong有you一yi群qun特te有youde组zu织zhi驻zhu留下liu巨噬shi细胞baon（AXL 、FCGR3A ），在睾丸wan中，zhong也ye存cun在zai一yi群qun特te中有youde组zu织zhi驻zhu留下liu巨ju噬shixibao(MMP9) ）与he一yi群qun具ju有you破po骨gu细胞bao特征zhengde巨ju噬shi细胞bao(ACP9 、SIGLEC15 、MMP9 ）。 本ben研究yan研究jiu首shou次ci在zai胚pei胎taiduo个ge之外的wai周zhou组zu编zhi(皮pi皮肤fui)、在心xin脏zang和ji睾gao丸wan)中zhong鉴jian定ding出chu一yi群qun和yu小xiao胶jiao质zhi细胞bao有you相xiang，类似于shi基ji因yin表biao达daopu特te征zheng的de巨ju噬shi细胞bao。zhe一yi发fa现xian打da破poliao小xiao胶jiao质zhixibao只zhi存cun在zai于yu脑nao和jiji髓sui中zhong的de传zhan统tong认ren知zhi。zhe一yi发fa现xian打da破poliao小xiao胶jiao质zhixibao只zhi存cun在zai于yu脑nao和jiji髓sui中zhong的de传zhan统tong认ren知zhi乐于官网。bao高gao表biaodap2R1、TMEM119、SALL1、C3等deng与yu小xiao胶jiao质zhi细胞bao相xiang同tongdete征zheng基ji因yin，zai无wu监jian监du聚ju类lei分fen析xizhong，这个zhe群qun细xibao和henaoo、zhong在脊ji髓sui中的de小xiao胶jiao质zhi细胞bao聚ju为wei一yi类lei。因yin这ci，研yan研究jiu将jiang这zhe群qun新xin发faian现xiande分fen布bu在zaiduo个ge外wai周zhou组zuzhidexibao命名ming为weilei小xiao胶jiao质zhi细胞bao（Microglia-like cells）。流liu式shi分fen析xi进jin一yi步bu验yan证zhengliao这zhong外wai周zhou组zhong中zhong的de类leiao胶jiao质zhi细胞bao和yu中zhong中zhong中zhong的de类liao胶jiao质zhi细胞bao，显示xianCD45lowpry12 MRC1-de表biaoxing。此ci外wai，研yan研究jiu基ji在yuduo重zhong免mian疫yi荧ying光guang实shi验yan发fa现xian，lei小xiao胶jiao质zhixibao Stages 12(CS12)时shi期qi已yi出chu现在xian在zai表biao皮pi组zu织zhi中zhong。在zai14 PCW之zhi前qian，类lei小xiao胶jiao质zhi细胞bao一yi直zhi是shi表biao皮pi中zhong最zui主zhu要yaode免mianyi细胞bao，在这个ci之后，hou细xibao比bi例li才cai开kaishi逐zhujian减jian少shao，在zai20 PCW之zhi之后hou，基ji本ben被pi朗lang格子汉han斯si细胞bao代替tidai。zhong在zai胚pei胎tai心脏zang中，类lei小xiao胶jiao质zhi细胞bao最早zao出chu现在zaiCS13中zhong（aorta）中zhong，并且在zai26中bing PCW之zhi前qian一yi直zhi是shi主zhu动dong脉mo中zhong最zui主zhu要yaode免mianyixi细胞bao。而er成cheng人ren主zhong动dong脉mo组zhongzhizhong则ze检jian测ce不bu到dao这zhe群qun类lei小xiao胶jiao质zhixibao。zhong在zai胚pei胎tai睾丸wan中，类lei小xiao胶jiao质zhi细胞baozui早zaong在zaiCS14de时shi候hou被pi检jian测ce到dao，zhu要yao存cun在zai附fu睾gaoo（epididymis）中zhongde输shu出chu小xiao管guanng（efferent duct）周zhou围wei，而er在zai睾gao丸wan实shizhi（parenchyma）zhong比bi例lize低于jiaodi。  研yan研究jiu显示xian显示shi，表biao皮pi和he中zhong枢shushen通过jing系统xi统tongjun从yu外wai胚pei层ceng开始，而er主zhu动dong脉mo和he附fu睾gao则ze起qi源yuanyuzhu动dong脉mo-性xingxian-中zhong肾shen（aorta-gonad-mesonephro，AGM）区qu域yu。研yan研究jiu推tui测ce，小xiao胶jiao质zhi细胞bao以yi和ji类lei小xiao胶jiao质zhi细胞baode前qian体ti从cong卵luang囊nang迁到dao外wai胚pei层ceng和heagM区quyu，而er后hou在zaizhe两liang个ge区qu域yu独duli分fenhua为wei小xiao胶jiao质zhi细胞bao或huo类leiao胶jiao质zhi细胞bao。 you在yu类lei小xiao胶jiao质zhi细xibao在zai表biao皮pi中zhong最zui是wei丰feng富fu，gai团tuandui进入jin一yi步bu研yan研究jiuliao，zhong可以在zai表biao皮pi组zuizhi中zhongdeng。研yan研究jiu发fa现xian，类lei小xiao胶jiao质zhi细胞bao在zai背beibu和he头toubu表biao皮pi中zhong比biao高。在zai9 PCW时shi，背bei部bu表biao皮pi中zhong几jihusuo有youde免mian疫yixi细胞baojun是shilei小xiao胶jiao质zhi细胞bao，在er四si肢zhi表biao皮pi中zhong约yue60%的de免疫yixi细胞bao是shilei小xiao胶jiao质zhixi细胞bao。进入jin一yi步bu定ding量liang分fen析xi表biao明ming，在zai胚pei胎tai发fa育yu不bu与tong阶jie段duan，背bei部bububiao皮pideliaobiao质zhiao细xibaodu比bi四si肢zhi表biao皮pidugduo，分fen布bu更geng密mi集ji。  类lei小xiao胶jiao质zhixi细胞bao在zai表biao皮pi中zhong的de极jihua分fen布bu模mushi和yu神shen通过jing茱萸jixi细胞baoo（neural crest cells，NCCs）de背bei外wai侧zhai迁qian移yi路lu线xian（dorsolateral migration）有you类lei类似shizhi的chu，因yin而er研究yan研究jiu推tui测ce表biao皮pideleliao胶jiao质zhi细胞bao和yuncszhi之间jian可以neng在zaimou种zhong中存储cun。NCCS是shi外wai胚pei层ceng衍生yan生sheng的de多duo可以neng干gan细xi胞bao，wai侧zhai迁移qian移动yi时，shi可以ke分化hua为wei黑hei色sesuibaoobaoooi（melanocytes）。研yan研究jiu通tong通过guo多duo重zhong免疫yi荧ying光guang实shi验yan发送fa现xian，表biao皮pi中zhong的delelei小xiao胶jiao质zhi细胞bao和hencs之zhi之间的jian存cun在zai直zhi接jie的de相xiang中相互hu作为zuong。与yu之zhi一yi致zhi的de是shi，gai团tuan观看guan观察cha到daolei小xiao胶jiao质量zhibao和he黑hei色sesumibaobao（melanoblasts）de密度duo在zai不bu与tong发送fa育yu阶jie段duan沿yan表biao皮pide背bei-侧zhai-腹fu轴zhou（dorsal-lateral-ventral axis）逐zhujian逐渐降低xiangdi。 　 为weiliao评ping评gu类lei小xiao胶jiao质zhi细胞bao对duiaoshen经jingjini细胞bao分feninghuaing的de影ying，gai研究yan研究jiu体ti外wai培养yang，liao来lai源yuan在yu胚pei胎tai背bei部bu的de新xin鲜xian皮肤fu组zu织zhi块kuai。zhong清qing除chu类leiao胶jiao质zhi细胞bao显xianzhuo减jian少shaoliao，这个zhe提ti显示shi类lei小xiao胶jiao质zhi细xi细胞bao可ke可以nenghui调zhou控kong神shen经jing细xi细胞bao向xiang黑hei色seisu细xi细胞bao的de分fen化hua。  gai研究yan研究jiu在zaiduo个gezangqizhong中zhong都duingding到dao一yi群qun高gao表biaoda促cu血xue管guan生sheng（VEGFA、TNF、IL1B、de巨ju噬shi细xi胞bao，CXCL8/IL8)。与tong时shi，这个zhe群qun细xi胞bao在zai不bu与tongzu编织zhi中zhong都有you相xiang类似shi的de基ji因yin表biaodapu。体ti外wai成cheng管guan实shi验yan也ye证明zheng实shiliao这zhe群qun细xi胞bao促使cu血xue管guan生sheng成cheng。进入jin一yi步bu，分fen分析xi发送fa现xian，这个zhe群qun细xibao在zai各ge个gezangqi中zhong全部jun富fu集ji在zai血xue管guan周zhou围wei。  研yan研究jiu进入jin一yi步bu分fen分析xiliao这zhe群qun促cu血xue管guan生sheng成cheng巨ju噬shi细胞baode发fa育yu起qian。科ke研yan人ren员yuan通过guo多duo种zhong拟ni时shi序xu分fen分析xi算suan法fa推tui断duan这zhe群quan细xi胞bao是shi从cong卵luan黄huang囊nang开始qi源yuan的de巨大ju噬shi细胞bao前qian体ti分fen化huan，而且在qie中zhong间jian经jinglililiao一ygexiang对dui不bu成chengshu的de前qian体tizhuang状态tai（pre-PraM）。拟ni时shi序xu分fen析xi推tui计算shan出chu的de分fen化hua轨guitji和yu细xibaodezhen实shi采cai样yang时shi间jian高gao度duo一yi致zhi，而qieqi促cu血xue管guan生sheng成cheng信xin号hao也ye在zai随suizhi增加zeng强qiang。此ci外wai，研yan研究jiu团tuan队dui采cai用yong成cheng管guangde内nei皮pi细胞baoshang清qing液ye培养yang来lai源yuanyuanyluang黄huang囊nang前qian体ti，发送fa现xian可ke诱导you导dao出chu表biao达da促使cu血xue管guan生sheng成cheng基jiyinde巨ju噬shi细xi胞bao。上shang描述shu成cheng果guo明显ming确实queliao这zhe群qun促使cu血xue管guan生sheng成cheng巨ju噬shi细胞baode发fayu起qi源yuan。  总zong和eryan之zhi，gai研究yan研究jiu通tong，通过guo对dui人ren类lei产chan前qian阶jie段duan近jin30万wan个ge免mianyi细xi胞bao的de单shan细胞bao转zhan录lu组zu分fen分析xi，用zhuo重zhong描述miaohui，liao15种zhong巨ju噬shi细胞bao亚ya型xingdeshi空kong动dong态tai变bian化hua。gai研究yan研究jiu突破po性xingde发fa现xianliao一yi群qun在zai转zhuan录lu组zu、特别tezheng蛋dan白bai表biao达da和hexing状态tai上的shang和yu中zhong枢shu神shen通过jing系xi统tong中zhong的de小xiao胶jiao质zhi细xi细胞bao类lei就像shi和qie存cun在zai上的pi皮肤fu、睾gao丸wan和he心脏zang中zhong的deleleiao胶jiao质zhi细胞bao。它的ta们men是shi早zao期qi表biao皮pi中zhong的de主zhu要yao免mian疫yi细xi胞bao群qun，沿yan背bei-侧zhai-腹fu轴zhou呈cheng极jihua分fen布bu。这个zhe群qun类lei小xiao胶jiao质zhixi细胞baoke以yi和yu神shen通过jingjiji细胞baoxiang相xiang作为zuo使用yong，bing调zhou节jietietietion通过jingjingjingbao相xiang作为zuong。通过guo功gong可以neng、jiang间的特征zheng、de研yan研究jiu，分为fen化hua轨gui迹ji，科ke研yan团tuan队dui细xi致zhi解xie分析xiliao一yizhong尚shang未wei被pi充chong分fenliao解xiede促cu血xue管guan生sheng成chengzhong未wei。这zhexie促cu血xue管guan生sheng成cheng巨ju噬shi细胞bao和yu小xiao胶jiao质zhi细胞bao都jun从cong开始，qi源yuan在yu卵luang黄huang囊nang前qian体ti分fenhuan。gai成cheng果guo为wei探tan讨tao人ren类lei巨ju噬shi细胞baode异yizhi性xing和he发fa育yu提ti，为gong提供liao高gao分fenshang动dong动dongtai图tupu，有you帮zhu在yu剖pou分析xiqi在zai发fa育yu通过guo程chengzhong的de不bu与tong作zuong。此ci外wai，gai团tuan队dui打开kai发送liao专zhuan门mende可ke视shi化hua平pingtai（http://119.8.23.169/)方fang便piang共gong享受xiang数shu据ju，推动cu进入jin研究yan研究jiu成为cheng果guo的de共gong与tong探索tan索suo、he领导ling域yu发送fa展zhan。  lun文wen链lian接jietu1. 构建jian人ren类lei免mian疫yi系统xitong发送fa育yu时shi空kong图tupu图tu2. 巨jushiao前qian体tifenhua为wei小xiao胶jiao质zhiaobao/类liao胶jiao质zhiaobao和he促cuiaue管guan生sheng；类lei小xiao胶jiao质zhixi细胞bao在zai表biao皮pi和yu神shen经jingjiji细胞bao互hu作zuo，bing调zhou控制kongqi分fen化hua图tu3. 孙xun悟wu空kong猴hou毛mao变bian出chu多duo种zhong猴hou子zideqing节jie寓yu意yi卵luan黄huang囊nang来lai源yuande巨ju噬shi细xibao前qian体ti向xiang不bu同tong细xibao亚ya群qunde分fenhuang　　陈chen女rushi和he黄huang先xian生sheng分fen别bie因yin声sheng音yin嘶哑ya和he咽ye喉hou不bu适shi来lai到dai院yuan五wu官guan科kejiushen，在jin行xing电dian子zizhou镜jing检查jian查zha之后，hou发送fa现xian，陈chen女ru士shidesheng带daishang、黄huang先xian生sheng的de舌she根gen部budu分fen别bie长zhang有you一yige“新xin生sheng物wu”，必bi必须xu要yao切qie除chu，陈chen女rushi右you侧zhai声sheng带daishang有you一yge巨ju大da的de“新xin生shengwu”，考kao考虑lv是shi息xi肉rou，比如ru果guo用yong用yong到wang的de电diangzizingjingjingjieyou，可ke可以neng残can留下liu导dao，zhi复fu发fade概gai率shuai会hui增加zeng大dai；黄huang先xian生sheng舌shengbu有you大da，er深shende“新xin生sheng物wu”，用yong电diangzizhou镜jing手shou，另外，ye不bu可以neng完成wang整zheng切qie除chu之外，er和qie出chu血xue难nuo以yi控kong制zhi，例如ru果guo传zhuan统tong开kai喉hou手shou术zhu的de话hua，手shou术zhu创chuang伤shang面miang积ji比jiao大da，恢hui复fude时，shi间jian比jiao长zhang，综zong合he考kao考虑lv，决jue定ding采cai用yong全quan麻ma支zhi支持cheng咽喉hou镜jing下xia低di温wen等deng离li子zie切qie除chu技zhu来lai为wei这zhe两liangwei切qie除chu这zhe两liang。

　　大da江jiang网wang 通过ton讯xun员yuan刘liu金jin添加tian、黄huang安an、王wang国guohui报bao道dao：近jin日ri，在zai全quan麻ma支zhi支持chenghouing下，xia使用yong低di温wen等deng离li子zi技术jizhu，分fen别bie为wei两liang名称ming患huanzhe完成wan成cheng声sheng带dai息xi肉rou和he咽ye部bu肿zhong物wu切qie除chu技术zhu，这个zhe一yi技术zhude开kai展zhan，是shishi城cheng百bai姓xing的de福fuzhi，为wei部bu分fen鼻bi咽yehou患huanzhe免除chuliao远yuan到fu大da城chengshi求qiu医yi的de劳lao顿dun，节jie省xingliao不bu少shaode医yi疗liao费用fei用yong，让rang优you质zhide医yiao资zi源yuan惠hui和ji更geng多duo百baixing。

　　手术zhu后hou两liangwei患huanzhe恢复hui复fu良lianghao，咽喉hou部bu无wu出chu血xue情qing状况kuang，全部jun在zaizhu后hou三san天tian康kang复fu出chuan。据ju悉xi，在zai同tong等deng县xuan级ji可以neng开kai展zhan这个ci技jizhu的de医yi医院yuan不bu多duo，这个zhe标biao志zhi在zai微wei创建chuang技术zhu治zhiliao早zao期qi喉hou部bu肿zhong块kuai方fang面mianmai上shangliao一yi个ge新xin台taijie。　　五wu官guan科ke团tuan队dui在zai熊xiong外wai到lai主zhu任rende带dai领ling下xia，手shou术zhu如ru期qi进入jin行xing，在zai全quan麻ma支zhi支持cheng喉hou镜jing下，xia用yong低di温wen等deng离li子zizhou方fangshi，顺shun利li将ba陈chen女rushi和he黄huang先xian生sheng的de声sheng带dai息xi肉rou和he舌shengenshongwu切qie除chu。

　　jingdian中zhong药yao配pei比bi方fang法fa50对dui，生sheng活huo中zhong可ke用yong到dao，简jian直zhi太taizhen贵gui，每个mei个geren都有du值zhi得到dei收shou藏zang和he分享xiang

　　导dao语yu ： 中zhong药yaode知zhi识shi博bo大da精jing深shen，好hao多duo人ren用yong一yi生shengde时shianjian去qu研yan研究jiu，简jian简jian单shan单shan拿na起qiang三san种zhongyao材caijiu可ke用yipei成cheng一yi副pifangzi，但是dan是shizenyao用yong，ji量liang是shi多duo少shao，这zhe更是shi一yizhong学习xue问wen。下xia面mian是shi为wei大da家jia整zheng理lidede，通过jingdianzhong药yao与pei比bi方fang法fa50对dui，简jian直zhi太taizhen贵gui，每个meigerendendeidenzhidengzhidenzhidi。

　　结jie语yu ：关guan在yu中zhong药yao一yi定ding要yao静jing心xin，专zhuan心xin专zhuan注zhude研yan研究jiu，切qie记ji心xin浮fu气qinzao。de50对dui中的zhong药yao配pei比bi方fang法fa，在zai生sheng活huo中的zhongchongchongchongchuohu可以用yong到yidao，非fei常chang的de使shi使用yong，为weiliao自ziji和he家jia人ren的de健jian康kang，收shou藏zang和he分fen享xiang　　57岁sui的de王wang先生xiangsheng生shengshen体ti一yi直zhi非fei常chang健jiang康kang，几ji天tian前qian感gan觉jue咽ye喉hou不bu舒shufu，以yi为wei是shi感gan冒mo就jiu没有mo在zai意yi。但是dang近jin三san天tian咽ye喉hou痛teng加jia重zhong，吞tunye困难nuo，直zhi。、呼hu吸xi困kun难nuo，以yi通过jing验yan判pan断duan为wei急ji性xing会hui厌yan炎yan。这个zheshi患huan者zhe出chu现xianliao剧ju烈lie的de烦fan躁zao，瞬间shun间jian就jiu失shi去quliao意yi识shi，李li大da夫fu当dang机ji立liguan抢jiangqi气qi管guan切qie打开kai通to

　　近jin日ri，在zai哈haler滨bin务wu工gong的de王wang先xian生sheng，因yin急ji性xing会hui厌yan炎yan引yin发fa呼hu吸xi困kun困难nuo危险wei和ji生sheng生命ming，到dao黑helong江jing省xing医院yuannnan岗gang分fen院yuan急诊zhen抢qiang救jiu，医院yuan和ji时shi组zu组织zuzhi抢qiang救jiu，挽wan救jing。

　　引yin起qi会hui厌yan炎yande原yuan因yin很henduo，比如ru喝yin酒jiuo、已经过了duo劳lao疲劳、胃wei酸suan刺cition、呕ou吐tu、鱼yu刺ci扎zhang等deng都是shi潜qian在zai诱you因yin。以yi目mu前qiande医yi治疗liao水shui平ping，只有zhi要yao人renmen能够neng重zhong视shi起qi来lai，急ji性xing会hui厌yan炎yan这zhe种zhong高gao危weibingbing是shi完wan全quanke以yi避bi免miandede。

　　根据ju参shen和yu抢qiang救jiu的de史shiyu明ming副pingzhu任ren介jie介绍shao，hui厌yan炎yan是shi比jiao为weichang看到xiang的de疾病bing，但dan引yin发fa急jixing发fa作zuo的de相xiang对dui比jiao少shao。、有you异yi物wu感gan，略shao重zhong一yi点dian的de甚shen至zhi不bu可以neng饮用ye水shui。但是dan非常hen少shao可以neng引yin起qi患huan的zhe重zhong视shi，直zhi到zhi引yin发fa急jing喉hou梗geng塞se制造zao成cheng呼hu吸xi困难nuo。例如ru果guo抢qiang救jiu不bu和ji时shi会ji。

　　见xian习xijizhe 郑zhen

　　特te约yuejizhe 李li明minhua 佟tong艾yi玲lingling

　　微wei博bo推tuini | 今jin日ri微wei博bo热redian：SN024）